Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
We Have The Best Solutions for Your Business
Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
What NMN Supplements Do?
NMN supplements are mainly used to increase NAD+ levels to improve metabolic diseases and slow down the aging process.
Improve metabolic diseases: Studies have shown that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity.
Delay the aging process: NMN can increase the vitality of cells, improve the metabolic process of cells, and delay the aging process.
Protect DNA: NAD+ is an important metabolic substance in cells and participates in various biological processes such as cellular energy metabolism and DNA repair. Supplementing NMN can increase NAD+ levels and protect DNA.
Improves Athletic Capacity: NMN has been shown to improve athletic performance and increase fat burning ability
Improve neurodegenerative diseases: Studies have shown that NMN can improve neurodegenerative diseases, such as Alzheimer's disease
However, these studies were small, and NMN has not been shown to be effective in clinical trials, so further research is needed to determine the effectiveness of NMN supplements.
What diseases can NMN supplements treat?
NMN (Nicotinamide Mononucleotide) is a substance similar to vitamin B3, which can produce NAD+ (a key metabolic intermediate) in the body. Therefore, studies have shown that NMN may help improve aging-related health issues such as metabolism, immunity, cell repair, brain health, and more.
Currently, NMN supplements are mainly used to treat the following diseases:
Aging-related metabolic disorders such as diabetes, obesity, high cholesterol, etc.
Aging-related neurodegenerative diseases, such as Alzheimer's disease.
Aging-associated immune decline.
Aging-related cardiovascular disease.
What are the purposes of NMN supplements?
NMN supplements are mainly used to increase NAD+ levels to improve metabolic diseases and slow down the aging process.
Improve metabolic diseases: Studies have shown that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity.
Delay the aging process: NMN can increase the vitality of cells, improve the metabolic process of cells, and delay the aging process.
Protect DNA: NAD+ is an important metabolic substance in cells and participates in various biological processes such as cellular energy metabolism and DNA repair. Supplementing NMN can increase NAD+ levels and protect DNA.
Improves Athletic Capacity: NMN has been shown to improve athletic performance and increase fat burning ability
Improve neurodegenerative diseases: Studies have shown that NMN can improve neurodegenerative diseases, such as Alzheimer's disease
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Frequently Asked Question
Do you have any question?
NMN supplements may cause side effects such as upset stomach, diarrhea, and nausea. There is also research showing that NMN supplements may affect insulin sensitivity and insulin levels, so people with diabetes should consult their doctor before taking them.
NMN supplements have not yet undergone large-scale clinical trials to verify their effectiveness. Currently, research on NMN supplements is mainly focused on animal and in vitro experiments. These studies show that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity, and can delay the aging process.
The long-term health effects of NMN supplementation are not well studied. Existing studies mainly focus on animal and in vitro experiments, which show that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity, and can delay the aging process. However, the results of these studies do not represent the long-term effects of NMN on human health.
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Maternal NAD Precursor Supplementation to Reduce the Risk of Developing CNDD
1. Introduction Nicotinamide adenine dinucleotide (NAD) has been unveiled to be essential for embryonic development. Patients with genetic variants in the NAD+ de novo synthesis pathway often have congenital NAD deficiency disorder (CNDD), a multisystem condition inherited in an autosomal recessive manner. In the context of NAD+ deficiency, all organs and systems, not just vertebrae, heart, kidneys, and limbs, may be affected. 2. The association between NAD synthetase 1 (NADSYN1) and CNDD Individuals delivering biallelic NADSYN1 variants share similar clinical features to those with CNDD. Up till now, almost all of the identified CNDD cases can be attributed to biallelic loss-of-function variants in any of 3 nonredundant genes of the NAD de novo synthesis pathway, including kynureninase (KYNU), 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), or NADSYN1. Among individuals with CNDD identified to date, those with biallelic pathogenic NADSYN1 variants are the most diverse in phenotype. 3. The impact of NADSYN1 variants upon enzymatic activity and phenotype Specifically, NADSYN1 can catalyse the amidation of nicotinic acid adenine dinucleotide (NaAD) to NAD. Biallelic pathogenic variants in NADSYN1 cause a metabolic block in both the de novo pathway and the Preiss-Handler pathway, leading to NAD deficiency. Biallelic NADSYN1 loss-of-function variants impact the NAD metabolome of humans. Post-birth phenotypes involve feeding difficulties, developmental delay, short stature, etc. 4. Mouse embryogenesis disrupted by the loss of NADSYN1 In NADSYN1-/- mouse embryos, NAD-dependent malformations occur when maternal dietary NAD precursors are limited during gestation. The affected Nadsyn1-/- embryos most frequently present malformations of the kidneys, eyes, and lungs. 5. The preventative effect of amidated NAD precursor supplementation against CNDD NADSYN1-dependent embryo loss and malformation in mice are preventable by dietary supplementation of amidated NAD precursors (NMN and NAM) during pregnancy. Maternal diet–derived NAD precursors primarily determine the development of healthy embryos. 6. Conclusion NAD-boosting supplements are essential for individuals with biallelic loss-of-function variants in NADSYN1. Maternal NAD precursor supplementation, to some extent, can reduce the risk of developing CNDD. Reference Szot JO, Cuny H, Martin EM, et al. A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder. J Clin Invest. 2024;134(4):e174824. Published 2024 Feb 15. doi:10.1172/JCI174824 About BONTAC BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 170 global patents as well as strong R&D team consisting of Doctors and Masters. BONTAC has rich R&D experience and advanced technology in the biosynthesis of NAD and its precursors (eg. NMN and NR), with various forms to be selected (eg. endoxin-free IVD-grade NAD, Na-free or Na-containing NAD; NR-CL or NR-Malate). High quality and stable supply of products can be better ensured here with the exclusive Bonpure seven-step purification technology and Bonzyme Whole-enzymatic method. Disclaimer This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.
Innovating Solutions: BONTAC's Biotechnology Product Offerings
Innovating Solutions: BONTAC's Biotechnology Product Offerings In the ever-evolving landscape of biotechnology products, BONTAC remains a trailblazer in providing cutting-edge solutions that drive innovation and progress. Our commitment to excellence is demonstrated through our diverse range of exceptional products, unwavering technical support, continuous pursuit of technical innovation, and extensive business coverage. At BONTAC, we are dedicated to empowering businesses across various industries with our pioneering biotechnology solutions. Cutting-Edge Biotechnology Products by BONTAC Discover the depth and breadth of BONTAC's unparalleled biotechnology product range, designed to address a wide array of industry needs. From advanced research tools to revolutionary bio-based materials, each product is a testament to our dedication to pushing the boundaries of biotechnological advancement. Our products embody the latest scientific insights and technological breakthroughs, ensuring that they meet the highest standards of quality and performance. At the heart of our offerings lies a cutting-edge portfolio of biotechnology products that encompass a wide range of applications. Whether you are engaged in advanced scientific research or seeking revolutionary bio-based materials, BONTAC's product range is designed to cater to diverse industry needs. Each product we offer is a testament to our relentless dedication to pushing the boundaries of biotechnological advancement. Features and Benefits of BONTAC's Biotechnology Products Explore the unique characteristics and benefits that set BONTAC's biotechnology solutions apart in the market. Our products are meticulously crafted to enhance efficiency, sustainability, and productivity in various applications. Customers who have embraced BONTAC's biotechnology offerings have experienced transformative results, showcasing the tangible impact of our products on their operations and outcomes. We understand that the success of businesses across industries hinges on access to the latest tools and technologies. That's why BONTAC's biotechnology products embody the latest scientific insights and technological breakthroughs. Our team of experts combines deep domain knowledge with rigorous research and development efforts to ensure that our products meet the highest standards of quality, reliability, and performance. Collaborating with BONTAC for Biotechnology Excellence Partnering with BONTAC opens doors to tailored biotechnology solutions that align with your specific business requirements. Our team of experts provides unparalleled technical support to guide you through product selection, integration, and optimization. By leveraging BONTAC's technical expertise and innovative product portfolio, businesses can drive forward their biotechnology initiatives with confidence and success. Long-term partnerships with BONTAC foster a culture of continuous innovation and mutual growth. Conclusion In conclusion, BONTAC is your trusted partner in navigating the dynamic world of biotechnology products. Embrace our excellent products, technical support, and commitment to technical innovation to elevate your biotechnology endeavors. With BONTAC by your side, you can harness the power of cutting-edge biotechnology solutions to drive your business forward and shape a brighter future.
The Application of NMN in Improving Oocyte Quality in T1D Mice
Introduction Reproductive dysfunction is frequent in female suffering from type 1 diabetes (T1D), up to 40% of whom will develop a variety of reproductive dysfunctions throughout their lives. T1D patients often have a declined oocyte maturation rate and low-quality oocytes. Noteworthily, nicotinamide mononucleotide (NMN) has been ascertained to be effective in improving the maturation rate and oocyte quality, which brings new hope to diabetic patients who are plagued by infertility problems. The detrimental effect of T1D on reproductive function T1D is harmful to the oocyte maturation, pre-implantation embryo development and pregnancy outcome, which can lead to delayed menarche, menstrual cycle abnormalities, ovulatory dysfunction, polycystic ovary syndrome, low fertility, pregnancy complications, and potential early menopause. The mother with T1D could produce fetuses with higher incidences of malformations and death. T1D can diminish the ovarian size and ovarian weight to some extent, raising the risk of infertility. Under diabetic condition, elevated glucose can diminish the extrusion rate of first polar body, thereby impairing the growth and development ability of oocytes. The effects of NMN on oocyte maturation of mouse with T1D mouse NMN can recover actin dynamics, as signified by the substantially elevated actin fluorescence intensity on the plasma membrane of the diabetic mouse oocytes following NMN treatment. In addition, NMN reverses meiotic defects in in vitro matured oocytes of the mice with diabetes. The spindle defects are frequently observed in MII oocytes of the mice with diabetes, while NMN supplementation markedly reduces the frequency of defect spindles caused by diabetes. Meanwhile, NMN improves the mitochondrial function of in vitro matured diabetic oocytes, as indicated by the restored mitochondrial signals as well as the dramatically increased levels of genes related to mitochondrial fusion (Opa1, Mfn2) and mitochondrial fission (Drp1) in in vitro matured diabetic oocytes post NMN treatment. Oocyte quality is prone to be affected by high ROS-induced DNA damage in diabetes. Remarkably, NMN can reduce ROS level, attenuate DNA damage, and reduce oxidative stress, as manifested by decreased ROS level, weak γH2A.X signal and upregulated mRNA level of anti-oxidation Sod1, respectively. Furthermore, the histone acetylation and methylation play important roles in oocyte maturation and early embryo development. Herein, aberrant histone modifications caused by diabetes are restored by NMN, as evidenced by the elevated levels of Sirt1 and Sirt3 as well as weak H4K16acin signal and strong H3K4me3 signal in diabetic oocytes following NMN treatment. Conclusion NMN might be an effective reagent to improve in vitro maturation percentage of oocytes and oocyte quality from female mice with diabetes partially through improving mitochondrial function, reversing meiotic defects, reducing ROS level, rescuing actin dynamics, suppressing DNA damage and restoring histone modifications, which provides a significant clue for the treatment of infertility of the patients with diabetes. Reference [1] Guo F, Wang L, Chen Y, Zhu H, Dai X, Zhang X. Nicotinamide Mononucleotide improves oocyte maturation of mice with type 1 diabetes. Nutr Diabetes. 2024;14(1):23. doi:10.1038/s41387-024-00280-8 [2] Thong EP, Codner E, Laven JSE, Teede H. Diabetes: a metabolic and reproductive disorder in women. Lancet Diabetes Endocrinol. 2020;8(2):134-149. doi:10.1016/S2213-8587(19)30345-6 BONTAC NMN BONTAC is the pioneer of NMN industry and the first manufacturer to launch NMN mass production, with the first whole-enzyme catalysis technology around the world. At present, BONTAC has become the leading enterprise in niche areas of coenzyme products. Our services and products have been highly recognized by global partners. Furthermore, BONTAC has the first national and the only provincial independent coenzyme engineering technology research center in Guangdong, China. The coenzyme products of BOMNTAC are widely used in fields such as nutritional health, biomedicine, medical beauty, daily chemicals and green agriculture. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, or costs arising directly or indirectly from your reliance on the information and material on this website.