NMN vs NR: Perbezaan utama
Satu kajian berwibawa yang baharu telah hadir! Satu eksperimen pada tahun 2025 oleh pasukan Northwest A&F University, yang diterbitkan dalam Journal of Microbiology (Core Journal, DOI: 10.13343/j.cnki.wsxb.20250174), mendedahkan dengan data yang telitia the true health effects of NMN and NR—two NAD+ precursors that both support gut health, fight inflammation and oxidation, yet each has its own distinct strengths. After reading this, you’ll never have to struggle over which to choose again!
BAHAGIAN 01
The Common Power: NMN and NR Both Build the Body’s Foundation
The study divided 45 C57 mice into three groups: one control group drinking plain water, and two groups gavaged with NMN or NR (400 mg/(kg·d), 5 times per week). After 8 weeks, the results were astonishing: both compounds achieved consensus in regulating gut health and metabolism.
Mengimbangi semula mikrobiota usus: Bakteria yang lebih bermanfaat, lebih stabil
The gut microbiota functions like a “miniature ecosystem”—the richer and more balanced it is, the healthier the host. The experiment found that after NMN or NR supplementation, the “richness” (Chao1 index) and “diversity” (Shannon index) of gut microbiota in mice increased significantly, meaning more beneficial bacteria and fewer harmful ones.
Rajah 1: Kesan pemakanan NMN dan NR terhadap kepelbagaian mikrob usus pada tikus.
A: Comparison of intestinal microbial α-diversity between the control and NMN groups;
B: Comparison of intestinal microbial α-diversity between the control and NR groups.
The dominant bacterial phyla also shifted: Bacteroidota (responsible for nutrient absorption and immune regulation) and Pseudomonadota increased, while Actinomycetota (associated with inflammation when imbalanced) decreased, without causing dysbiosis—essentially adding a “stabilizer” to the gut.
Rajah 2: Kesan pemakanan NMN dan NR terhadap kepelbagaian mikrob usus pada tikus.
C: Kelimpahan spesies peringkat filum dalam kumpulan yang diberi makan NMN;
D: Kelimpahan spesies peringkat filum dalam kumpulan NR-fed
Peningkatan Berganda Anti-Radang dan Antioksidan: Melindungi Kesihatan dari Metabolisme ke Gen
Keradangan dan kerosakan oksidatif adalah punca utama kepada banyak gangguan. NMN dan NR menentang mereka dari kedua-dua pihak:
Metabolically: both significantly upregulated anti-inflammatory fatty acid metabolites such as oleic acid and linoleic acid, as well as antioxidant metabolites like salicylic acid—adding a “natural defense shield” to the body.
Rajah 3: Peta haba metabolit berbeza dalam kumpulan NMN-fed
Rajah 4: Peta haba metabolit berbeza dalam kumpulan NR-fed
Genetically: quantitative PCR testing confirmed that both compounds inhibited the expression of pro-inflammatory factors such as TNF-α and IL-6, effectively reducing inflammation at its source.
Rajah 5: Kesan pemberian NMN dan NR terhadap faktor keradangan usus pada tikus.
A: PCR expression of tumor necrosis factor-α (TNF-α);
B: Ekspresi PCR interleukin 6 (IL-6);
BAHAGIAN 02
Perbezaan Utama: Memilih NMN atau NR untuk Pengoptimuman Kesihatan yang Tepat
While they share core benefits, the study clearly identified each compound’s area of expertise. Choose according to your needs for double the results.
NMN: The “Guardian” of Gut Barrier Health
If you often experience gut discomfort or worry about mucosal damage, NMN is the better choice. It significantly increases the number of goblet cells in the colon—these “mucus factories” secrete protective mucus that forms a physical barrier between harmful bacteria and intestinal epithelium, enhancing gut resistance. NMN also more strongly modulates gut microbiota diversity and strengthens local immunity through the “Bacteroidota–fatty acid” axis—essentially a personalized gut health solution.
Rajah 6: Statistik sel goblet dalam kolon tikus
Figure 7: Comparison of intestinal microbial α-diversity among mice in the control, NMN, and NR groups
NR: The “Booster” for Muscle Vitality
Want to improve muscle strength and reduce fatigue? NR shines here! Surprisingly, mice in the NR group showed significantly higher grip strength than those in the NMN and control groups. Mechanistically, NR upregulates metabolites like arachidic acid (for membrane repair) and L-asparagine (for energy optimization), activates core energy pathways such as the TCA cycle, and downregulates oxidative stress markers like hydroquinone—essentially “energizing and unburdening” muscles for peak performance.
Figure 8: Statistics of mice’s grasping ability
BAHAGIAN 03
Choose According to Your Needs—Science Over Guesswork
Penemuan tahun 2025 menjelaskan dengan jelas: NMN dan NR bukanlah pengganti tetapi pilihan yang saling melengkapi. Sama ada matlamat anda adalah melindungi kesihatan usus atau meningkatkan tenaga fizikal, memilih prekursor NAD+ yang tepat yang disokong oleh literatur berwibawa memberikan kesihatan anda lapisan dua lapisan kepastian.
BAHAGIAN 04
Bontac Bio’s NR Malate: Excellence in NR Technology and Quality
Sejak 2012, Bontac Bio telah menjadi sebuah perusahaan berteknologi tinggi yang mengkhusus dalam teknologi biokatalisis. Dalam membangunkan dan menghasilkan NR Malate (NRHM), syarikat ini menggabungkan kepakaran dan inovasi uniknya, mempamerkan kelebihan teknikal dan produk yang luar biasa.
Exclusive Technological Edge: Bontac Bio’s NR Malate holds the world’s first crystal form patent, achieving a molecular-level breakthrough that optimizes product performance. As a pioneer in the NMN industry, Bontac applies its globally original all-enzyme catalytic process—an innovation leading the industry. To date, the company has filed over 200 domestic and international invention patents and established China’s first provincial Coenzyme Engineering Technology Research Center, building strong competitive advantages through solid R&D strength.
Uncompromising Product Quality: Bontac enforces rigorous quality control standards. Third-party testing by CTI confirmed that NR Malate contains no detectable cadmium, mercury, lead, or arsenic—ensuring safety from the source. High-performance liquid chromatography revealed almost no impurity peaks, while moisture and microbial indicators far exceeded industry standards, reflecting exceptional purity. Critically, stability testing showed that under normal light-protected conditions, Bontac NR Malate degraded at only half the rate of regular NR (NRCL), ensuring reliable quality in both long-term storage and product applications.
Pematuhan dan Pensijilan: Bontac memegang pensijilan antarabangsa FSSC 22000, Self-GRAS, FDA, Kosher, dan HALAL, memastikan pematuhan penuh dengan piawaian global dari R&D hingga pengeluaran. Kajian tambahan, termasuk ujian anti-fotoaging dan tahap NAD+ ikan zebra, mengesahkan lagi keberkesanan dan potensinya.
Today, Bontac NR Malate is steadily advancing in compliant applications. For more insights into NR technology or premium product development, follow Bontac Bio—an industry leader in coenzyme biotechnology dedicated to sharing its R&D stories and quality standards.
BAHAGIAN 01
The Common Power: NMN and NR Both Build the Body’s Foundation
The study divided 45 C57 mice into three groups: one control group drinking plain water, and two groups gavaged with NMN or NR (400 mg/(kg·d), 5 times per week). After 8 weeks, the results were astonishing: both compounds achieved consensus in regulating gut health and metabolism.
Mengimbangi semula mikrobiota usus: Bakteria yang lebih bermanfaat, lebih stabil
The gut microbiota functions like a “miniature ecosystem”—the richer and more balanced it is, the healthier the host. The experiment found that after NMN or NR supplementation, the “richness” (Chao1 index) and “diversity” (Shannon index) of gut microbiota in mice increased significantly, meaning more beneficial bacteria and fewer harmful ones.
Rajah 1: Kesan pemakanan NMN dan NR terhadap kepelbagaian mikrob usus pada tikus.
A: Comparison of intestinal microbial α-diversity between the control and NMN groups;
B: Comparison of intestinal microbial α-diversity between the control and NR groups.
The dominant bacterial phyla also shifted: Bacteroidota (responsible for nutrient absorption and immune regulation) and Pseudomonadota increased, while Actinomycetota (associated with inflammation when imbalanced) decreased, without causing dysbiosis—essentially adding a “stabilizer” to the gut.
Rajah 2: Kesan pemakanan NMN dan NR terhadap kepelbagaian mikrob usus pada tikus.
C: Kelimpahan spesies peringkat filum dalam kumpulan yang diberi makan NMN;
D: Kelimpahan spesies peringkat filum dalam kumpulan NR-fed
Peningkatan Berganda Anti-Radang dan Antioksidan: Melindungi Kesihatan dari Metabolisme ke Gen
Keradangan dan kerosakan oksidatif adalah punca utama kepada banyak gangguan. NMN dan NR menentang mereka dari kedua-dua pihak:
Metabolically: both significantly upregulated anti-inflammatory fatty acid metabolites such as oleic acid and linoleic acid, as well as antioxidant metabolites like salicylic acid—adding a “natural defense shield” to the body.
Rajah 3: Peta haba metabolit berbeza dalam kumpulan NMN-fed
Rajah 4: Peta haba metabolit berbeza dalam kumpulan NR-fed
Genetically: quantitative PCR testing confirmed that both compounds inhibited the expression of pro-inflammatory factors such as TNF-α and IL-6, effectively reducing inflammation at its source.
Rajah 5: Kesan pemberian NMN dan NR terhadap faktor keradangan usus pada tikus.
A: PCR expression of tumor necrosis factor-α (TNF-α);
B: Ekspresi PCR interleukin 6 (IL-6);
BAHAGIAN 02
Perbezaan Utama: Memilih NMN atau NR untuk Pengoptimuman Kesihatan yang Tepat
While they share core benefits, the study clearly identified each compound’s area of expertise. Choose according to your needs for double the results.
NMN: The “Guardian” of Gut Barrier Health
If you often experience gut discomfort or worry about mucosal damage, NMN is the better choice. It significantly increases the number of goblet cells in the colon—these “mucus factories” secrete protective mucus that forms a physical barrier between harmful bacteria and intestinal epithelium, enhancing gut resistance. NMN also more strongly modulates gut microbiota diversity and strengthens local immunity through the “Bacteroidota–fatty acid” axis—essentially a personalized gut health solution.
Rajah 6: Statistik sel goblet dalam kolon tikus
Figure 7: Comparison of intestinal microbial α-diversity among mice in the control, NMN, and NR groups
NR: The “Booster” for Muscle Vitality
Want to improve muscle strength and reduce fatigue? NR shines here! Surprisingly, mice in the NR group showed significantly higher grip strength than those in the NMN and control groups. Mechanistically, NR upregulates metabolites like arachidic acid (for membrane repair) and L-asparagine (for energy optimization), activates core energy pathways such as the TCA cycle, and downregulates oxidative stress markers like hydroquinone—essentially “energizing and unburdening” muscles for peak performance.
Figure 8: Statistics of mice’s grasping ability
BAHAGIAN 03
Choose According to Your Needs—Science Over Guesswork
Penemuan tahun 2025 menjelaskan dengan jelas: NMN dan NR bukanlah pengganti tetapi pilihan yang saling melengkapi. Sama ada matlamat anda adalah melindungi kesihatan usus atau meningkatkan tenaga fizikal, memilih prekursor NAD+ yang tepat yang disokong oleh literatur berwibawa memberikan kesihatan anda lapisan dua lapisan kepastian.
BAHAGIAN 04
Bontac Bio’s NR Malate: Excellence in NR Technology and Quality
Sejak 2012, Bontac Bio telah menjadi sebuah perusahaan berteknologi tinggi yang mengkhusus dalam teknologi biokatalisis. Dalam membangunkan dan menghasilkan NR Malate (NRHM), syarikat ini menggabungkan kepakaran dan inovasi uniknya, mempamerkan kelebihan teknikal dan produk yang luar biasa.
Exclusive Technological Edge: Bontac Bio’s NR Malate holds the world’s first crystal form patent, achieving a molecular-level breakthrough that optimizes product performance. As a pioneer in the NMN industry, Bontac applies its globally original all-enzyme catalytic process—an innovation leading the industry. To date, the company has filed over 200 domestic and international invention patents and established China’s first provincial Coenzyme Engineering Technology Research Center, building strong competitive advantages through solid R&D strength.
Uncompromising Product Quality: Bontac enforces rigorous quality control standards. Third-party testing by CTI confirmed that NR Malate contains no detectable cadmium, mercury, lead, or arsenic—ensuring safety from the source. High-performance liquid chromatography revealed almost no impurity peaks, while moisture and microbial indicators far exceeded industry standards, reflecting exceptional purity. Critically, stability testing showed that under normal light-protected conditions, Bontac NR Malate degraded at only half the rate of regular NR (NRCL), ensuring reliable quality in both long-term storage and product applications.
Pematuhan dan Pensijilan: Bontac memegang pensijilan antarabangsa FSSC 22000, Self-GRAS, FDA, Kosher, dan HALAL, memastikan pematuhan penuh dengan piawaian global dari R&D hingga pengeluaran. Kajian tambahan, termasuk ujian anti-fotoaging dan tahap NAD+ ikan zebra, mengesahkan lagi keberkesanan dan potensinya.
Today, Bontac NR Malate is steadily advancing in compliant applications. For more insights into NR technology or premium product development, follow Bontac Bio—an industry leader in coenzyme biotechnology dedicated to sharing its R&D stories and quality standards.
